Article
Genetic susceptibility to visceral leishmaniasis in The Sudan: linkage and association with IL4 and IFNGR1.
Genes and immunity - 1 Jul 2003
Mohamed H S, Ibrahim M E, Miller E N, Peacock C S, Khalil E A G, Cordell H J, Howson J M M, El Hassan A M, Bereir R E H, Blackwell J M
Abstract excerpt
Longitudinal studies in Sudan show ethnic differences in incidence and clinical phenotypes associated with Leishmania donovani. Immunologically, bias in type 1 vs type 2 cytokine responses is important. To determine whether polymorphisms at IL4/IL9 or IFNGR1 contribute to susceptibility, we examined 59 multicase families of visceral leishmaniasis (VL) with/without post Kala-azar dermal leishmaniasis (PKDL)....
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