Article
Classification and regression tree and spatial analyses reveal geographic heterogeneity in genome wide linkage study of Indian visceral leishmaniasis.
PloS one - 31 Dec 2010
Fakiola Michaela, Mishra Anshuman, Rai Madhukar, Singh Shri Prakash, O'Leary Rebecca A, Ball Stephen, Francis Richard W, Firth Martin J, Radford Ben T, Miller E Nancy, Sundar Shyam, Blackwell Jenefer M
Abstract excerpt
BACKGROUND: Genome wide linkage studies (GWLS) have provided evidence for loci controlling visceral leishmaniasis on Chromosomes 1p22, 6q27, 22q12 in Sudan and 6q27, 9p21, 17q11-q21 in Brazil. Genome wide studies from the major focus of disease in India have not previously been reported. METHODS AND FINDINGS: We undertook a GWLS in India in which a primary ∼10 cM (515 microsatellites) scan was carried out in 58...
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