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Article

Aurora Kinase A is a Biomarker for Bladder Cancer Detection and Contributes to its Aggressive Behavior

19 Jan 2017

Abstract excerpt

The effects of AURKA overexpression associated with poor clinical outcomes have been attributed to increased cell cycle progression and the development of genomic instability with aneuploidy. We used RNA interference to examine the effects of AURKA overexpression in human bladder cancer cells. Knockdown had minimal effects on cell proliferation but blocked tumor cell invasion. Whole genome mRNA expression...

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Share to Bladder and Urothelial Cancer Treatments
Share to Epigenetics and DNA Methylation
Share to RNA modifications and cancer

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PMID: 28102366
DOI: 10.1038/srep40714

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