Incorporating phenotype-dependent growth rates into the color-shift model for preneoplastic hepatocellular lesions.

Abstract excerpt

Multi-stage models occupy a central position in modeling the carcinogenesis process. These models formalize the hypothesis that cells have to undergo several transformations on their way to malignancy. This hypothesis assumes that a preneoplastic cell of a later stage arises through a mutational event of a single cell of a previous stage and that preneoplastic cells proliferate clonally. However, there is some...

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