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Article

Two stage model for carcinogenesis: number and size distributions of premalignant clones in longitudinal studies.

Mathematical biosciences - 1 Jan 1999

Dewanji A, Goddard M J, Krewski D, Moolgavkar S H

Abstract excerpt

The two stage clonal expansion model of carcinogenesis provides a convenient biologically based framework for the description of toxicologic and epidemiologic data on carcinogenesis. Under this model, a cancer cell is generated following the occurrence of two critical mutations in a single stem cell. Initiated cells that have sustained the first mutation undergo a stochastic birth-death process resulting in...

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Identifiers

PMID: 10024832
DOI: 10.1016/s0025-5564(98)10049-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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