A model for hepatocarcinogenesis with clonal expansion of three successive phenotypes of preneoplastic cells.

Abstract excerpt

The two-stage model with clonal expansion of intermediate cells has often been used to describe the carcinogenesis process. The model hypothesizes that cells have to undergo two mutations on their way from the normal to the malignant stage. Biological experiments indicate the existence of three types of preneoplastic cells in hepatocarcinogenesis representing three successive intermediate stages in the...

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