Rate-limiting steps in carcinogenesis and their bearing on the incidence/age data for cutaneous melanoma and hepatocellular carcinoma.

Abstract excerpt

We analyze published data on cancer incidence as a function of age for (i) cutaneous melanoma for cohorts of males in Connecticut and (ii) hepatocellular cancer in Mozambique, China and Romania, on the basis of multi-hit models for carcinogenesis. The simple multi-hit model suggests an unlikely scenario in which, as the cohorts advance or the intensity of mutagenesis increases, fewer mutations are required to...

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