Rate-limiting steps in carcinogenesis and their bearing on the incidence/age data for cutaneous melanoma and hepatocellular carcinoma.

Abstract excerpt

We analyze published data on cancer incidence as a function of age for (i) cutaneous melanoma for cohorts of males in Connecticut and (ii) hepatocellular cancer in Mozambique, China and Romania, on the basis of multi-hit models for carcinogenesis. The simple multi-hit model suggests an unlikely scenario in which, as the cohorts advance or the intensity of mutagenesis increases, fewer mutations are required to...

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Carcinoma, Hepatocellular
• Cell Transformation, Neoplastic
• Child
• Connecticut
• Humans
• Liver Neoplasms
• Male