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Article

Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12-transgenic mice.

European journal of immunology - 1 Sept 2002

Lucas Mathias, Daniel Laurent, Tomasello Elena, Guia Sophie, Horschowski Nicole, Aoki Naoko, Figarella-Branger Dominique, Gomez Sophie, Vivier Eric

Abstract excerpt

KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. We report here the characterization of transgenic mice that overexpress KARAP/DAP12 polypeptides in both myeloid and lymphoid compartments. KARAP/DAP12-transgenic mice present, in a transgene dose-dependent...

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Source

Identifiers

PMID: 12207350
DOI: 10.1002/1521-4141(200209)32:9<2653::AID-IMMU2653>3.0.CO;2-V

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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