Article
The CD300e molecule in mice is an immune-activating receptor.
The Journal of biological chemistry - 9 Mar 2018
Isobe Masamichi, Izawa Kumi, Sugiuchi Masahiro, Sakanishi Tamami, Kaitani Ayako, Takamori Ayako, Maehara Akie, Matsukawa Toshihiro, Takahashi Mariko, Yamanishi Yoshinori, Oki Toshihiko, Uchida Shino, Uchida Koichiro, Ando Tomoaki, Maeda Keiko, Nakano Nobuhiro, Yagita Hideo, Takai Toshiyuki, Ogawa Hideoki, Okumura Ko, Kitamura Toshio, Kitaura Jiro
Abstract excerpt
CD300 molecules (CD300s) belong to paired activating and inhibitory receptor families, which mediate immune responses. Human CD300e (hCD300e) is expressed in monocytes and myeloid dendritic cells and transmits an immune-activating signal by interacting with DNAX-activating protein 12 (DAP12). However, the CD300e ortholog in mice (mCD300e) is poorly characterized. Here, we found that mCD300e is also an...
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