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Article

KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions

9 May 2005

Abstract excerpt

The signaling adaptor protein KARAP/DAP12/TYROBP (killer cell activating receptor-associated protein / DNAX activating protein of 12 kDa / tyrosine kinase binding protein) belongs to the family of transmembrane polypeptides bearing an intracytoplasmic immunoreceptor tyrosine-based activation motif (ITAM). This adaptor, initially characterized in NK cells, is associated with multiple cell-surface activating...

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PMID: 15884055
DOI: 10.1002/eji.200425932

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