Article
Coronary artery calcification is related to functional polymorphism of matrix metalloproteinase 3: the Helsinki Sudden Death Study.
Atherosclerosis - 1 Oct 2002
Pöllänen Perttu J, Lehtimäki Terho, Ilveskoski Erkki, Mikkelsson Jussi, Kajander Olli A, Laippala Pekka, Perola Markus, Goebeler Sirkka, Penttilä Antti, Mattila Kari M, Syrjäkoski Kirsi, Koivula Timo, Nikkari Seppo T, Karhunen Pekka J
Abstract excerpt
Matrix metalloproteinase 3 (MMP3) is expressed in human coronary atherosclerotic lesions and is known to be involved in degradation of the plaque and to be co-localized with calcium and fibrin deposits in advanced lesions, indicating a possible role of MMP3 in arterial calcification. The MMP3 gene promoter polymorphism leads to low promoter activity 6A6A, intermediate promoter activity 5A6A and high promoter...
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