Article
Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques.
Atherosclerosis - 1 May 2005
Pöllänen Perttu J, Lehtimäki Terho, Mikkelsson Jussi, Ilveskoski Erkki, Kunnas Tarja, Perola Markus, Penttilä Antti, Mattila Kari M, Nikkari Seppo T, Syrjäkoski Kirsi, Karhunen Pekka J
Abstract excerpt
OBJECTIVE: Matrix metalloproteinases 3 and 9 (MMP3 and MMP9) are present in atherosclerotic plaques and co-operate in the degradation of the fibrous cap of the atheroma, leading to fissuring and ultimately to acute coronary thrombosis. The functional genetic polymorphisms in the promoters of MMP3 and MMP9, which lead to low- and high-transcription activity genotypes, have been shown to be associated with...
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