Genotype-phenotype association of matrix metalloproteinase-3 polymorphism and its synergistic effect with smoking on the occurrence of acute coronary syndrome.

Abstract excerpt

Matrix metalloproteinase-3 (MMP-3) degrades the extracellular matrix and may contribute to the weakening of the plaque cap. To determine whether genotype-phenotype associations differed in different categories of acute coronary syndrome, we enrolled 650 consecutive Taiwanese patients diagnosed with acute coronary syndrome. Genotypic analysis was done on DNA using polymerase chain reaction and direct sequencing on...

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