Article
Coronary artery complicated lesion area is related to functional polymorphism of matrix metalloproteinase 9 gene: an autopsy study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2001
Pöllänen P J, Karhunen P J, Mikkelsson J, Laippala P, Perola M, Penttilä A, Mattila K M, Koivula T, Lehtimäki T
Abstract excerpt
Matrix metalloproteinase 9 (MMP9) is expressed in human atherosclerotic plaques, and the protein is localized in human coronary atherosclerotic lesions. The MMP9 gene has a C-to-T promoter polymorphism at position -1562, which affects transcription and leads to promoter low-activity (C/C) and high-activity (C/T, T/T) genotypes. To determine whether these genotypes exert an influence on the atherosclerotic lesion...
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