Article
ras Gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas.
Archives of pathology & laboratory medicine - 1 Sept 2002
Yoo Jinyoung, Park Sonya Y, Robinson Robert A, Kang Seok Jin, Ahn Woong Shick, Kang Chang Suk
Abstract excerpt
OBJECTIVE: To investigate ras gene alteration in human gastric adenocarcinomas and its potential relationship to ras signal transduction mediators. DESIGN: Genomic DNA from 104 gastric tumors were analyzed by sequencing of polymerase chain reaction-amplified products for the presence of ras mutations. All the samples were further investigated with the use of immunohistochemical analysis for ERK1 and ERK2....
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