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Article

EGFR, HER-2 and KRAS in canine gastric epithelial tumors: a potential human model?

PloS one - 1 Jan 2014

Terragni Rossella, Casadei Gardini Andrea, Sabattini Silvia, Bettini Giuliano, Amadori Dino, Talamonti Chiara, Vignoli Massimo, Capelli Laura, Saunders Jimmy H, Ricci Marianna, Ricci Marianna, Ulivi Paola, Ulivi Paola

Abstract excerpt

Epidermal growth factor receptor (EGFR or HER-1) and its analog c-erbB-2 (HER-2) are protein tyrosine kinases correlated with prognosis and response to therapy in a variety of human cancers. KRAS mediates the transduction of signals between EGFR and the nucleus, and its mutation has been identified as a predictor of resistance to anti-EGFR drugs. In human oncology, the importance of the EGFR/HER-2/KRAS signalling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24454858
DOI: 10.1371/journal.pone.0085388
PMCID: PMC3893207

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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