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Article

Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein.

Nucleic acids research - 1 Sept 2002

Li Baomin, Comai Lucio

Abstract excerpt

The DNA-dependent protein kinase (DNA-PK) complex, which is composed of a DNA-dependent kinase subunit (DNA-PKcs) and the Ku70/80 heterodimer, is involved in DNA double-strand break repair by non-homologous end joining (NHEJ). Ku70/80 interacts with the Werner syndrome protein (WRN) and stimulates WRN exonuclease activity. To investigate a possible function of WRN in NHEJ, we have examined the relationship...

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Source

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Identifiers

PMID: 12202749
DOI: 10.1093/nar/gkf488
PMCID: PMC137412

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein.PMID 12202749Read ↗

Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by PhosphorylationSemantic proximity Read ↗

Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loopsSemantic proximity Read ↗

Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.Semantic proximity Read ↗

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids.Semantic proximity Read ↗

Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome ProteinSemantic proximity Read ↗

The DNA‐dependent protein kinase: the director at the endSemantic proximity Read ↗

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.Semantic proximity Read ↗

How to fix DNA breaks: new insights into the mechanism of non-homologous end joiningSemantic proximity Read ↗

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIPSemantic proximity Read ↗

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.Semantic proximity Read ↗

Interplay between Ku, Artemis, and the DNA-dependent Protein Kinase Catalytic Subunit at DNA EndsSemantic proximity Read ↗

Double strand break rejoining by the Ku-dependent mechanism of non-homologous end-joining.Semantic proximity Read ↗

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