Article
The role of the TP73 gene and its transcripts in neuro-oncology.
British journal of neurosurgery - 1 Oct 2014
Jancalek Radim
Abstract excerpt
Protein p73 is a member of the p53 protein family that can induce cell cycle arrest or apoptosis by the activation of p53-responsive genes as well as p53-independent pathways. Alternative promoter usage, together with differential splicing of the C-terminal exons, forms several distinct mRNAs that are translated into corresponding protein isoforms containing different domains. While TAp73 isoforms respond to...
Topics
- Animals
- Cell Transformation, Neoplastic
- Central Nervous System Neoplasms
- DNA-Binding Proteins
- Humans
- Mutation
- Nuclear Proteins
- Protein Isoforms
- Transcription, Genetic
- Tumor Protein p73
- Tumor Suppressor Protein p53