Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression but lack of mutation and methylation of p73 in hepatocellular carcinoma.

Acta oncologica (Stockholm, Sweden) - 1 Jan 2002

Pan Huichin, Liao Shu-Ju, Lai Wen-Yung, Lu Hsi-Chi, Hsiao Kuang-Ming

Abstract excerpt

p73 is one of the family proteins that share structural and functional homologies with the tumor suppressor p53. To analyze the status of p73 in hepatocellular carcinoma (HCC), the allelic loss, allelic expression, mutation and methylation status of the p73 gene were examined in 18 paired HCC and normal tissues. No allelic loss was found. All heterozygous individuals contained RNA of both alleles, indicating that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Liver Neoplasms

Share to Loss of Heterozygosity

Share to Polymorphism, Single-Stranded Conformational

Share to Tumor Protein p73

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 12546528
DOI: 10.1080/02841860214968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression but lack of mutation and methylation of p73 in hepatocellular carcinoma.PMID 12546528Read ↗

Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma.Semantic proximity Read ↗

Allelic expression of the putative tumor suppressor gene p73 in human fetal tissues and tumor specimens.Semantic proximity Read ↗

Genetic alternations of p73 are infrequent but may occur in early stage hepatocellular carcinoma.Semantic proximity Read ↗

Overexpression of the wild type p73 gene in human bladder cancer.Semantic proximity Read ↗

Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53.Semantic proximity Read ↗

P73 gene expression in ovarian cancer tissues and cell lines.Semantic proximity Read ↗

Overexpression of the wild type p73 gene in breast cancer tissues and cell lines.Semantic proximity Read ↗

Mutation and expression analysis of the p73 gene in prostate cancer.Semantic proximity Read ↗

Methylation of the p73 gene in gliomas.Semantic proximity Read ↗

Elevated and biallelic expression of p73 is associated withprogression of human bladder cancer.Semantic proximity Read ↗

Infrequent somatic mutations of the p73 gene in various human cancers.Semantic proximity Read ↗

Frequent inactivation of the <i>p73</i> gene by abnormal methylation or LOH in non‐Hodgkin's lymphomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.