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Article

p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by Nef

1 Apr 2000

Abstract excerpt

The activation of Nef-associated kinase (NAK) by Nef from human and simian immunodeficiency viruses is critical for efficient viral replication and pathogenesis. This induction occurs via the guanine nucleotide exchange factor Vav and the small GTPases Rac1 and Cdc42. In this study, we identified NAK as p21-activated kinase 1 (PAK1). PAK1 bound to Nef in vitro and in vivo. Moreover, the induction of cytoskeletal...

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Identifiers

PMID: 10713183
DOI: 10.1128/mcb.20.7.2619-2627.2000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by NefPMID 10713183Read ↗

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