Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines.

Breast cancer (Tokyo, Japan) - 1 Jan 2002

Matsuo Fumie, Yano Ken-ichi, Saito Hiroko, Morotomi Keiko, Kato Masahiro, Yoshimoto Masataka, Kasumi Fujio, Akiyama Futoshi, Sakamoto Goi, Miki Yoshio

Abstract excerpt

BACKGROUND: Mammalian mel-18 is a member of the polycomb group, and it acts as a transcriptional repressor with DNA binding activity. Murine mel-18 negatively regulates the cell cycle through the c-myc/cdc25 cascade, and mice haploinsufficient for mel-18 develop mammary gland tumors. In addition, the human homolog of mel-18 is located at 17q, on which candidate tumor suppressor genes for breast cancer have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Loss of Heterozygosity

Share to Polycomb Repressive Complex 1

Share to Polymorphism, Single-Stranded Conformational

Share to Repressor Proteins

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12196719
DOI: 10.1007/BF02967544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines.PMID 12196719Read ↗

The novel tumor-suppressor Mel-18 in prostate cancer: its functional polymorphism, expression and clinical significance.Semantic proximity Read ↗

Mutation analyses of 268 candidate genes in human tumor cell lines.Semantic proximity Read ↗

Loss of the polycomb protein Mel-18 enhances the epithelial–mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancerSemantic proximity Read ↗

Loss, mutation and deregulation of L3MBTL4 in breast cancers.Semantic proximity Read ↗

Definition of regions of the human genome affected by loss of heterozygosity in primary human breast tumors.Semantic proximity Read ↗

The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.Semantic proximity Read ↗

Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line.Semantic proximity Read ↗

Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood.Semantic proximity Read ↗

Loss of Chromosome 18 in Neuroendocrine Tumors of the Small Intestine: The Enigma RemainsSemantic proximity Read ↗

Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis.Semantic proximity Read ↗

Mapping of a breast cancer tumor suppressor gene locus to a 4-cM interval on chromosome 18q21.Semantic proximity Read ↗

Somatic allelic deletion of nm23 in human cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.