Article
Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line.
Genes, chromosomes & cancer - 1 Apr 2005
Jakob John, Nagase Satoru, Gazdar Adi, Chien Minchen, Morozova Irina, Russo James J, Nandula Subhadra V, Murty Vundavalli V V S, Li Chi-Ming, Tycko Benjamin, Parsons Ramon
Abstract excerpt
Loss of chromosome arm 18q is a common event in human pancreatic, colon, and breast cancers and is often interpreted as representing loss of one or more tumor-suppressor genes. In this article, we describe two novel biallelic deletions at chromosome band 18q21.1 in a recently characterized human breast cancer cell line, HCC-1428. One lesion deletes a fragment of approximately 300 kb between SMAD4 and DCC that...
Topics
- Alleles
- Animals
- Breast Neoplasms
- COS Cells
- Cell Line, Tumor
- Chromosome Deletion
- Chromosome Painting
- Chromosomes, Artificial, Bacterial
- Chromosomes, Human, Pair 18
- DNA-Binding Proteins
- Humans
- Immunoblotting
- Polymerase Chain Reaction