Article
The -33T-->C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembolism, independently of the factor V Leiden and prothrombin mutations.
Thrombosis and haemostasis - 1 Aug 2002
Ameziane Nejma, Seguin Cendrine, Borgel Delphine, Fumeron Frédéric, Moatti Didier, Alhenc-Gelas Martine, Grandchamp Bernard, Aiach Martine, Emmerich Joseph, de Prost Dominique
Abstract excerpt
We have previously identified, in intron 7 of the TFPI gene, a T to C single-base polymorphism (-33T-->C) which is strongly associated with total circulating TFPI antigen levels. Here we examined the influence of this polymorphism on the risk of venous thromboembolism. The polymorphism was identified in the PATHROS study population (330 cases with venous thromboembolism and 826 controls). The CC genotype was...
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