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Article

The 536C→T Transition in the Human Tissue Factor Pathway Inhibitor (TFPI) Gene Is Statistically Associated with a Higher Risk for Venous Thrombosis

1 Jan 1999

Abstract excerpt

Tissue factor pathway inhibitor (TFPI) is an important regulator in the extrinsic blood coagulation pathway. Although the regulatory biochemical role of TFPI is evident, the clinical significance of this proteinase inhibitor remains to be elucidated. The definition of a clinical TFPI deficiency seems to be more complex than that of other coagulation inhibitors because the activity and concentration of circulating...

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PMID: 10456444
DOI: 10.1055/s-0037-1614619

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Related research

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The 536C→T Transition in the Human Tissue Factor Pathway Inhibitor (TFPI) Gene Is Statistically Associated with a Higher Risk for Venous ThrombosisPMID 10456444Read ↗

The -33T-->C polymorphism in intron 7 of the TFPI gene influences the risk of venous thromboembolism, independently of the factor V Leiden and prothrombin mutations.Semantic proximity Read ↗

Polymorphisms of the tissue factor pathway inhibitor gene are associated with venous thromboembolism in the antiphospholipid syndrome and carriers of factor V Leiden.Semantic proximity Read ↗

Genetic determinants of tissue factor pathway inhibitor plasma levels.Semantic proximity Read ↗

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A new T-287C polymorphism in the 5' regulatory region of the tissue factor pathway inhibitor gene. Association study of the T-287C and C-399T polymorphisms with coronary artery disease and plasma TFPI levels.Semantic proximity Read ↗

Cancer-associated thrombosis: What about microRNAs targeting the tissue factor coagulation pathway?Semantic proximity Read ↗

Functional characterization of polymorphisms in the human TFPI gene.Semantic proximity Read ↗

Factor XIII Val34Leu is a genetic factor involved in the etiology of venous thrombosis.Semantic proximity Read ↗

Tissue factor pathway inhibitor polymorphisms in women with and without a history of venous thrombosis and the effects of postmenopausal hormone therapy.Semantic proximity Read ↗

Polymorphisms in the TAFI gene and the risk of venous thrombosis.Semantic proximity Read ↗

A novel mutation in the F5 gene (factor V Amsterdam) associated with bleeding independent of factor V procoagulant function.Semantic proximity Read ↗

Association of Asn221Ser mutation in tissue factor pathway inhibitor-beta with plasma total tissue factor pathway inhibitor level.Semantic proximity Read ↗

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