Article
Genotypic variation in the promoter region of the protein C gene is associated with plasma protein C levels and thrombotic risk.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 1995
Spek C A, Koster T, Rosendaal F R, Bertina R M, Reitsma P H
Abstract excerpt
Protein C is a vitamin K-dependent zymogen of a serine protease that inhibits blood coagulation by proteolytic inactivation of factors Va and VIIIa. Individuals with protein C deficiency are at risk for thrombophlebitis, deep-vein thrombosis, and pulmonary embolism. Genetic analysis of a number o...
Topics
- Aged
- Base Sequence
- Case-Control Studies
- DNA Primers
- Genotype
- Humans
- Middle Aged
- Molecular Sequence Data
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Protein C
- Risk Factors
- Thrombosis