Article
Complex association of protein C gene promoter polymorphism with circulating protein C levels and thrombotic risk.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 1999
Aiach M, Nicaud V, Alhenc-Gelas M, Gandrille S, Arnaud E, Amiral J, Guize L, Fiessinger J N, Emmerich J
Abstract excerpt
The allele and haplotype frequency of the -1654 C/T and -1641 A/G protein C (PC) gene promoter polymorphisms was determined and analyzed according to circulating PC concentrations in 394 healthy subjects aged 20 to 60 years. The CG haplotype was associated with a lower PC concentration in both homozygous and heterozygous subjects compared with noncarriers. The TA allele had the reverse effect, but only in...
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