Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2005

Chen Yifang, Perry Daniel, Boackle Susan A, Sobel Eric S, Molina Hector, Croker Byron P, Morel Laurence

Abstract excerpt

The systemic lupus erythematosus 1 (Sle1) locus mediates the loss of tolerance to nuclear Ags in the NZM2410 mouse model of lupus through intrinsic defects in both B and T cells. Congenic analysis has shown that Sle1 corresponds to at least three genetic loci, Sle1a, Sle1b, and Sle1c. Telomeric Sle1c is associated with abnormal B cell responses to subthreshold stimulation with anti-IgM and C3d and with decreased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocyte Subsets
Share to Germinal Center

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Graft vs Host Disease

Share to Immunoglobulin M

Share to Mice, Congenic

Share to Mice, Inbred NZB

Share to Radiation Chimera

Share to Receptors, Complement 3d

Source

Identifiers

PMID: 16002709
DOI: 10.4049/jimmunol.175.2.1080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.PMID 16002709Read ↗

Augmentation of NZB autoimmune phenotypes by the Sle1c murine lupus susceptibility interval.Semantic proximity Read ↗

Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.Semantic proximity Read ↗

The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells.Semantic proximity Read ↗

A New Zealand Black-derived locus suppresses chronic graft-versus-host disease and autoantibody production through nonlymphoid bone marrow-derived cells.Semantic proximity Read ↗

Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms.Semantic proximity Read ↗

The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes.Semantic proximity Read ↗

Genetic determination of T cell help in loss of tolerance to nuclear antigens.Semantic proximity Read ↗

Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor γ.Semantic proximity Read ↗

The NZM2410-derived lupus susceptibility locus Sle2c1 increases Th17 polarization and induces nephritis in fas-deficient mice.Semantic proximity Read ↗

Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodiesSemantic proximity Read ↗

Genetic Dissection of SLESemantic proximity Read ↗

Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.