Article
The Bcl6 locus is not mutated in mouse B-cell lineage lymphomas.
Leukemia research - 1 Aug 2002
Hori Mitsuo, Qi Chen-Feng, Torrey Ted A, Huppi Konrad, Morse Herbert C
Abstract excerpt
In normal human germinal centre (GC) B-cells and post-GC B-cell lymphomas, a region in the first intron of the BCL6 gene, termed the major mutations cluster (MMC) exhibits somatic point mutations and deletions with patterns very similar to those seen in the variable regions of immunoglobulin (Ig) genes. In studies of mouse post-GC diffuse large cell lymphoma, Burkitt lymphomas, and plasmacytomas, direct...
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