Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutation of bcl-6 genes can occur in the absence of V(H) mutations in chronic lymphocytic leukemia.

Blood - 1 Jun 2000

Sahota S S, Davis Z, Hamblin T J, Stevenson F K

Abstract excerpt

Somatic mutation in immunoglobulin variable (V) region genes occurs largely in the germinal center and, after neoplastic transformation, imprints V genes of B-cell tumors with the mutational history of the cell of origin. Recently, it has been found that chronic lymphocytic leukemia (CLL) consists of 2 subsets, each with a different clinical course, one with unmutated V(H) genes consistent with a naive B cell,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Immunoglobulin
Share to Globins
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Karyotyping

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Proto-Oncogene Proteins c-bcl-6

Share to Proto-Oncogenes

Source

Identifiers

PMID: 10828040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutation of bcl-6 genes can occur in the absence of V(H) mutations in chronic lymphocytic leukemia.PMID 10828040Read ↗

BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

Identification of three subgroups of B cell chronic lymphocytic leukemia based upon mutations of BCL-6 and IgV genes.Semantic proximity Read ↗

Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia.Semantic proximity Read ↗

Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type.Semantic proximity Read ↗

BCL6: somatic mutations and expression in early-stage chronic lymphocytic leukemia.Semantic proximity Read ↗

Bcl-6 mutation status provides clinically valuable information in early-stage B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

Targeted somatic mutation of the BCL6 proto-oncogene and its impact on lymphomagenesis.Semantic proximity Read ↗

Determining mutational status of immunoglobulin v genes in chronic lymphocytic leukemia: a useful prognostic indicator.Semantic proximity Read ↗

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.Semantic proximity Read ↗

The occurrence and significance of V gene mutations in B cell-derived human malignancy.Semantic proximity Read ↗

Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.Semantic proximity Read ↗

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.