Article
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998
Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, Baldini L, Chaganti R S, Klein U, Küppers R, Rajewsky K, Dalla-Favera R
Abstract excerpt
The molecular mechanism involved in the process of antigen-driven somatic hypermutation of Ig genes is unknown, but it is commonly believed that this mechanism is restricted to the Ig loci. B cell lymphomas commonly display multiple somatic mutations clustering in the 5'-regulatory region of BCL-...
Topics
- B-Lymphocytes
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Genes, Immunoglobulin
- Germinal Center
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Leukemia, B-Cell
- Lymphoma, B-Cell
- Mutation
- Neoplasms
- Polymerase Chain Reaction