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Article

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998

Pasqualucci L, Migliazza A, Fracchiolla N, William C, Neri A, Baldini L, Chaganti R S, Klein U, Küppers R, Rajewsky K, Dalla-Favera R

Abstract excerpt

The molecular mechanism involved in the process of antigen-driven somatic hypermutation of Ig genes is unknown, but it is commonly believed that this mechanism is restricted to the Ig loci. B cell lymphomas commonly display multiple somatic mutations clustering in the 5'-regulatory region of BCL-6, a proto-oncogene encoding for a POZ/Zinc finger transcriptional repressor expressed in germinal center (GC) B cells...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

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Share to Polymorphism, Single-Stranded Conformational

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Source

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Identifiers

PMID: 9751748
DOI: 10.1073/pnas.95.20.11816
PMCID: PMC21723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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