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Article

Mutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice.

Mutation research - 2 Apr 2008

Louro Henriqueta, Pinheiro Inês, Costa Paula, Sousa Carla, Dias Anabela, Boavida Maria G, Silva Maria J

Abstract excerpt

Poly (ADP-ribose) polymerase-1 (Parp1) plays a central role in the maintenance of genomic integrity and has been unequivocally associated to DNA base excision repair (BER) but its involvement in double-strand break (DSB) repair pathways remains unclear. In this work, using transgenic Parp1-deficient mice harbouring the lacZ reporter gene, we provide in vivo evidence that Parp1 contributes to the prevention of...

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Identifiers

PMID: 18242645
DOI: 10.1016/j.mrfmmm.2007.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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