Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Review of 5-FU resistance mechanisms in colorectal cancer: clinical significance of attenuated on-target effects

1 Jan 2023

Abstract excerpt

The emergence of chemoresistant disease during chemotherapy with 5-Fluorouracil-based (5-FU-based) regimens is an important factor in the mortality of metastatic CRC (mCRC). The causes of 5-FU resistance are multi-factorial, and besides DNA mismatch repair deficiency (MMR-D), there are no widely accepted criteria for determining which CRC patients are not likely to be responsive to 5-FU-based therapy. Thus, there...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Colorectal Cancer Treatments and Studies
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37457133
DOI: 10.20517/cdr.2022.136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Review of 5-FU resistance mechanisms in colorectal cancer: clinical significance of attenuated on-target effectsPMID 37457133Read ↗

Molecular Mechanisms and Tumor Biological Aspects of 5-Fluorouracil Resistance in HCT116 Human Colorectal Cancer CellsSemantic proximity Read ↗

DNA mismatch repair (MMR)‐dependent 5‐fluorouracil cytotoxicity and the potential for new therapeutic targetsSemantic proximity Read ↗

Thymidylate Synthase: A Target for Combination Therapy and Determinant of Chemotherapeutic Response in Colorectal CancerSemantic proximity Read ↗

Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistanceSemantic proximity Read ↗

Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer TreatmentSemantic proximity Read ↗

Pharmacogenomics of 5-fluorouracil in colorectal cancer: review and updateSemantic proximity Read ↗

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporationSemantic proximity Read ↗

Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2′-Deoxyuridine in Colorectal Cancer Cell LinesSemantic proximity Read ↗

Novel opportunities for thymidylate metabolism as a therapeutic targetSemantic proximity Read ↗

An RNA damage response network mediates the lethality of 5-FU in colorectal cancerSemantic proximity Read ↗

5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processesSemantic proximity Read ↗

UBE2S promotes 5-fluorouracil resistance in colorectal cancer by activating non-canonical NF-κB/TYMS/TK1 signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.