Article

Overcoming Cisplatin Resistance in TP53-null Colon Cancer Organoids

2025-02-17

Abstract excerpt

Cisplatin chemotherapy of colorectal cancer (CRC) is associated with dose-limiting side effects and the development of drug resistance, resulting in reduced therapeutic effectiveness. The resistant phenotype in colon cancer is primarily due to changes in p53-regulated DNA damage signaling and /or defects in the cellular mismatch-repair pathway. Therefore, enhancing the efficacy of cisplatin chemotherapy remains a...

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Literature Corpus work: a5c8196a-dae1-5774-bbcd-ba21eef92b65
DOI: 10.1101/2025.02.12.637569

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