Methylenetetrahydrofolate reductase gene C677T polymorphism, plasma homocysteine and folate in end-stage renal disease dialysis and non-dialysis patients.

doi:10.1159/000064458

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Article

Methylenetetrahydrofolate reductase gene C677T polymorphism, plasma homocysteine and folate in end-stage renal disease dialysis and non-dialysis patients.

Nephron - 1 Sept 2002

Zychma Marcin J, Gumprecht Janusz, Grzeszczak Wladyslaw, Zukowska-Szczechowska Ewa

Abstract excerpt

BACKGROUND: It has been recently suggested that the presence of the methylenetetrahydrofolate reductase gene 677TT genotype is associated with younger age at initiation of dialysis, thus raising a hypothesis that younger renal patients carrying the TT genotype are at higher risk to develop end-stage renal disease. The aim of this study was to test the association between the C677T polymorphism and the presence of...

Topics

Adolescent
Adult
Age Factors
Disease Progression
Female
Folic Acid
Genetic Predisposition to Disease
Genotype
Homocysteine
Humans
Kidney Failure, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Methylenetetrahydrofolate Reductase (NADPH2)

Oxidoreductases Acting on CH-NH Group Donors

Polymorphism, Single Nucleotide

Renal Dialysis

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 12187113
DOI: 10.1159/000064458

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12187113-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Methylenetetrahydrofolate reductase gene C677T polymorphism, plasma homocysteine and folate in end-stage renal disease dialysis and non-dialysis patients.PMID 12187113Read ↗

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