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Article

Methylenetetrahydrofolate reductase gene C677T polymorphism, plasma homocysteine and folate in end-stage renal disease dialysis and non-dialysis patients.

Nephron - 1 Sept 2002

Zychma Marcin J, Gumprecht Janusz, Grzeszczak Wladyslaw, Zukowska-Szczechowska Ewa

Abstract excerpt

BACKGROUND: It has been recently suggested that the presence of the methylenetetrahydrofolate reductase gene 677TT genotype is associated with younger age at initiation of dialysis, thus raising a hypothesis that younger renal patients carrying the TT genotype are at higher risk to develop end-stage renal disease. The aim of this study was to test the association between the C677T polymorphism and the presence of...

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Source

Identifiers

PMID: 12187113
DOI: 10.1159/000064458

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Methylenetetrahydrofolate reductase gene C677T polymorphism, plasma homocysteine and folate in end-stage renal disease dialysis and non-dialysis patients.PMID 12187113Read ↗

The C677T methylenetetrahydrofolate reductase gene mutation in hemodialysis patients.Semantic proximity Read ↗

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Methylenetetrahydrofolate Reductase gene polymorphism in patients receiving hemodialysis.Semantic proximity Read ↗

The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphisms in essential hypertension relation: with the development of hypertensive end-stage renal disease.Semantic proximity Read ↗

An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease.Semantic proximity Read ↗

Hyperhomocysteinemia is related to residual glomerular filtration and folate, but not to methylenetetrahydrofolate-reductase and methionine synthase polymorphisms, in supplemented end-stage renal disease patients undergoing hemodialysis.Semantic proximity Read ↗

The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: results of a multicentre prospective study.Semantic proximity Read ↗

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Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients.Semantic proximity Read ↗

Correlations of MTHFR 677C>T polymorphism with cardiovascular disease in patients with end-stage renal disease: a meta-analysis.Semantic proximity Read ↗

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