Article
The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: results of a multicentre prospective study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Feb 2005
Aucella Filippo, Margaglione Maurizio, Grandone Elvira, Vigilante Mimmo, Gatta Giuseppe, Forcella Mauro, Ktena Maria, De Min Alva, Salatino Giovanna, Procaccini Deni Aldo, Stallone Carmine, Gesualdo Loreto
Abstract excerpt
BACKGROUND: Although the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism has been identified as an independent cardiovascular risk factor (CRF) in the general population and among uraemic subjects, the validity of this association remains controversial. METHODS: To verify this hypothesis, we enrolled all subjects on maintenance dialysis treatment from a specific Italian district. We also...
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