Article
An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease.
Kidney international - 1 Sept 2001
Wrone E M, Zehnder J L, Hornberger J M, McCann L M, Coplon N S, Fortmann S P
Abstract excerpt
BACKGROUND: It is unclear whether total serum homocysteine (tHcy) and the C677T mutation of methylenetetrahydrofolate reductase (MTHFR) are associated with cardiovascular disease (CVD) in patients with end-stage renal disease (ESRD). METHODS: A cross-sectional sample of 459 patients with ESRD on chronic dialysis was assessed to determine whether tHcy and the C677T mutation are associated with CVD prevalence in...
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