Prevalence of methylenetetrahydrofolate gene (MTHFR) C677T polymorphism among chronic hemodialysis patients and its association with cardiovascular disease: a cross-sectional analysis.

Abstract excerpt

INTRODUCTION: Cardiovascular disease (CVD) remains the main cause of morbidity and mortality in end stage renal disease (ESDR) patients. A common C-T mutation at nucleotide position 677 (C677T) has been identified in the gene coding for methylenetetrahydrofolate reductase (MTHFR), which is involved in the remethylation of homocysteine (Hcy). The C677T mutation decreases MTHFR activity, tends to increase Hcy...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiovascular Diseases
• Share to Cross-Sectional Studies