Article
Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients.
Kidney international - 1 Aug 1997
Födinger M, Mannhalter C, Wölfl G, Pabinger I, Müller E, Schmid R, Hörl W H, Sunder-Plassmann G
Abstract excerpt
Hyperhomocysteinemia is frequent in hemodialysis patients and represents an independent risk factor for vascular disease in these patients. Elevated total homocysteine (tHcy) plasma levels can results from defective remethylation of Hcy to methionine due to decreased activity of the enzyme methyl...
Topics
- Adult
- Aged
- Alleles
- Cohort Studies
- Female
- Folic Acid
- Gene Frequency
- Genotype
- Homocysteine
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Oxidoreductases Acting on CH-NH Group Donors
- Point Mutation
- Renal Dialysis
- Renal Insufficiency
- Vitamin B 12