Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients.

Kidney international - 1 Aug 1997

Födinger M, Mannhalter C, Wölfl G, Pabinger I, Müller E, Schmid R, Hörl W H, Sunder-Plassmann G

Abstract excerpt

Hyperhomocysteinemia is frequent in hemodialysis patients and represents an independent risk factor for vascular disease in these patients. Elevated total homocysteine (tHcy) plasma levels can results from defective remethylation of Hcy to methionine due to decreased activity of the enzyme methylenetetrahydrofolate reductase (MTHFR). A genetic aberration in the MTHFR gene (677 C to T substitution) has been shown...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alleles
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to MTHFR gene

Share to Genotype

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Point Mutation

Source

Identifiers

PMID: 9264011
DOI: 10.1038/ki.1997.362

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients.PMID 9264011Read ↗

The common mutations C677T and A1298C in the human methylenetetrahydrofolate reductase gene are associated with hyperhomocysteinemia and cardiovascular disease in hemodialysis patients.Semantic proximity Read ↗

Prevalence of methylenetetrahydrofolate gene (MTHFR) C677T polymorphism among chronic hemodialysis patients and its association with cardiovascular disease: a cross-sectional analysis.Semantic proximity Read ↗

The C677T methylenetetrahydrofolate reductase gene mutation in hemodialysis patients.Semantic proximity Read ↗

[Methylenetetrahydrofolate reductase gene polymorphism and plasma homocysteine levels in hemodialysing patients].Semantic proximity Read ↗

Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients.Semantic proximity Read ↗

Polymorphism in methylenetetrahydrofolate reductase gene: its impact on plasma homocysteine levels and carotid atherosclerosis in ESRD patients receiving hemodialysis.Semantic proximity Read ↗

Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients.Semantic proximity Read ↗

Increased prevalence of combined MTR and MTHFR genotypes among individuals with severely elevated total homocysteine plasma levels.Semantic proximity Read ↗

Methylenetetrahydrofolate Reductase gene polymorphism in patients receiving hemodialysis.Semantic proximity Read ↗

Hyperhomocysteinemia and polymorphisms of the methylenetetrahydrofolate gene in hemodialysis and peritoneal dialysis patients.Semantic proximity Read ↗

A C677T mutation in the methylenetetrahydrofolate reductase gene modifies serum cysteine in dialysis patients.Semantic proximity Read ↗

An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.