Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells.

Cancer research - 1 Sept 2001

Roh H, Green D W, Boswell C B, Pippin J A, Drebin J A

Abstract excerpt

Mutations involving the adenomatous polyposis coli (APC) tumor suppressorgene/beta-catenin signaling pathway have been identified in the majority of colon carcinomas. However, the role of aberrant beta-catenin signaling in the neoplastic growth of APC-mutant colon cancer cells has not been directly studied. To address this question, antisense oligonucleotides have been used to specifically down-regulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Colonic Neoplasms
Share to Genes, APC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Nude

Share to Neoplasm Transplantation

Share to Oligonucleotides, Antisense

Share to Thionucleotides

Share to Transplantation, Heterologous

Source

Identifiers

PMID: 11522655

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells.PMID 11522655Read ↗

Beta-catenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts.Semantic proximity Read ↗

Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells.Semantic proximity Read ↗

ShRNA-mediated gene silencing of β-catenin inhibits growth of human colon cancer cellsSemantic proximity Read ↗

Disruption of β-Catenin–Dependent Wnt Signaling in Colon Cancer Cells Remodels the Microenvironment to Promote Tumor InvasionSemantic proximity Read ↗

Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype.Semantic proximity Read ↗

Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner.Semantic proximity Read ↗

Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.Semantic proximity Read ↗

Disrupting ß-catenin dependent Wnt signaling activates an invasive gene program predictive of colon cancer progressionSemantic proximity Read ↗

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.Semantic proximity Read ↗

Proof-of-principle: oncogenic beta-catenin is a valid molecular target for the development of pharmacological inhibitors.Semantic proximity Read ↗

gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Semantic proximity Read ↗

Mutation of alpha-catenin results in invasiveness of human HCT-8 colon cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.