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Article

Impact of mutant β-catenin on ABCB1 expression and therapy response in colon cancer cells

29 Mar 2012

Abstract excerpt

BACKGROUND: Colorectal cancers are often chemoresistant toward antitumour drugs that are substrates for ABCB1-mediated multidrug resistance (MDR). Activation of the Wnt/β-catenin pathway is frequently observed in colorectal cancers. This study investigates the impact of activated, gain-of-function β-catenin on the chemoresistant phenotype. METHODS: The effect of mutant (mut) β-catenin on ABCB1 expression and...

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PMID: 22460269
DOI: 10.1038/bjc.2012.81

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