Article
Effect of katG mutations on the virulence of Mycobacterium tuberculosis and the implication for transmission in humans.
Infection and immunity - 1 Sept 2002
Pym Alexander S, Saint-Joanis Brigitte, Cole Stewart T
Abstract excerpt
The usefulness of isoniazid (INH), a key component of short-course chemotherapy of tuberculosis, is threatened by the emergence of drug-resistant strains of Mycobacterium tuberculosis with mutations in the katG gene. It is shown here that the most commonly occurring KatG mutation, where Ser 315 is replaced by Thr (S315T), is associated with clinically significant levels of INH resistance. In contrast to another...
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