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Article

Impact of isoniazid resistance on virulence of global and south Indian clinical isolates of Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2014

Ameeruddin Nusrath Unissa, Luke Elizabeth Hanna

Abstract excerpt

Isoniazid (INH) is the only anti-tuberculous drug for which a relationship has been noticed between acquisition of resistance and lack of virulence. Mutation in katG gene is the chief cause for INH resistance in Mycobacterium tuberculosis (MTB). Classical studies have demonstrated that INH-resistant (INH(r)) mutants with a defective katG gene were catalase deficient and markedly attenuated in guinea pigs. Also,...

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Identifiers

PMID: 25270728
DOI: 10.1016/j.tube.2014.08.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impact of isoniazid resistance on virulence of global and south Indian clinical isolates of Mycobacterium tuberculosis.PMID 25270728Read ↗

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