Article
Identification and analysis of mutations in the katG gene in multidrug-resistant Mycobacterium tuberculosis clinical isolates.
Pneumonologia i alergologia polska - 1 Jan 2013
Jagielski Tomasz, Grzeszczuk Magdalena, Kamiński Michał, Roeske Katarzyna, Napiórkowska Agnieszka, Stachowiak Radosław, Augustynowicz-Kopeć Ewa, Zwolska Zofia, Bielecki Jacek
Abstract excerpt
INTRODUCTION: A major role in the development of resistance of Mycobacterium tuberculosis to isoniazid (INH) is attributed to mutations in the katG gene coding for the catalase/peroxidase, an enzyme required for obtaining a pharmacologically active form of the drug. Analysis of mutations in the katG gene in M. tuberculosis strains may contribute to the development of reliable and rapid tests for detection of INH...
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