Article
First description of the katG gene deletion in a Mycobacterium tuberculosis clinical isolate and its impact on the mycobacterial fitness.
International journal of medical microbiology : IJMM - 1 May 2021
De Maio Flavio, Cingolani Antonella, Bianco Delia Mercedes, Salustri Alessandro, Palucci Ivana, Sanguinetti Maurizio, Delogu Giovanni, Sali Michela
Abstract excerpt
Isoniazid (INH) is the cornerstone of the anti-tuberculosis regimens and emergence of Mycobacterium tuberculosis (Mtb) resistant strains is a major threat to our ability to control tuberculosis (TB) at global level. Mutations in the gene coding the catalase KatG confer resistance to high level of INH. In this paper, we describe for the first time a complete deletion of the genomic region containing the katG gene...
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