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Article

Significance of catalase-peroxidase (KatG) mutations in mediating isoniazid resistance in clinical strains of Mycobacterium tuberculosis.

Journal of global antimicrobial resistance - 1 Dec 2018

Unissa Ameeruddin Nusrath, Doss C George Priya, Kumar Thirumal, Sukumar Swathi, Lakshmi Appisetty Ramya, Hanna Luke Elizabeth

Abstract excerpt

OBJECTIVES: Isoniazid (INH) is still the most important first-line antitubercular drug. INH resistance is regarded as a major impediment to the tuberculosis (TB) control programme and contributes to the emergence of multidrug-resistant strains. Mutation at position 315 in the katG gene, encoding the catalase-peroxidase (KatG) enzyme, is the major cause of INH resistance in Mycobacterium tuberculosis. Therefore,...

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Source

Identifiers

PMID: 29990547
DOI: 10.1016/j.jgar.2018.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Significance of catalase-peroxidase (KatG) mutations in mediating isoniazid resistance in clinical strains of Mycobacterium tuberculosis.PMID 29990547Read ↗

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