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Article

virB-Mediated survival of Brucella abortus in mice and macrophages is independent of a functional inducible nitric oxide synthase or NADPH oxidase in macrophages.

Infection and immunity - 1 Sept 2002

Sun Yao-Hui, den Hartigh Andreas B, Santos Renato Lima, Adams L Garry, Tsolis Renée M

Abstract excerpt

The Brucella abortus virB locus is required for establishing chronic infection in the mouse. Using in vitro and in vivo models, we investigated whether virB is involved in evasion of the bactericidal activity of NADPH oxidase and the inducible nitric oxide synthase (iNOS) in macrophages. Elimination of NADPH oxidase or iNOS activity in macrophages in vitro increased recovery of wild-type B. abortus but not...

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Identifiers

PMID: 12183526
DOI: 10.1128/IAI.70.9.4826-4832.2002
PMCID: PMC128286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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