Article
Inactivation of the type IV secretion system reduces the Th1 polarization of the immune response to Brucella abortus infection.
Infection and immunity - 1 Jul 2008
Rolán Hortensia García, Tsolis Renée M
Abstract excerpt
The Brucella abortus type IV secretion system (T4SS), encoded by the virB operon, is essential for establishing persistent infection in the murine reticuloendothelial system. To gain insight into the in vivo interactions mediated by the T4SS, we compared host responses elicited by B. abortus with those of an isogenic mutant in the virB operon. Mice infected with the B. abortus virB mutant elicited smaller...
Topics
- Animals
- Antibodies, Bacterial
- Bacterial Proteins
- Brucella abortus
- Brucellosis
- Cytokines
- Female
- Immunity
- Mice
- Mice, Inbred BALB C
- Mutation
- Operon