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Article

Identification of genes required for chronic persistence of Brucella abortus in mice.

Infection and immunity - 1 Jul 2000

Hong P C, Tsolis R M, Ficht T A

Abstract excerpt

The genetic basis for chronic persistence of Brucella abortus in lymphoid organs of mice, cows, and humans is currently unknown. We identified B. abortus genes involved in chronic infection, by assessing the ability of 178 signature-tagged mutants to establish and maintain persistent infection in mice. Each mutant was screened for its ability to colonize the spleens of mice at 2 and 8 weeks after inoculation....

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Identifiers

PMID: 10858227
DOI: 10.1128/IAI.68.7.4102-4107.2000
PMCID: PMC101704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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