Article
Host susceptibility to Brucella abortus infection is more pronounced in IFN-γ knockout than IL-12/β2-microglobulin double-deficient mice.
Clinical & developmental immunology - 1 Jan 2012
Brandão Ana Paula M S, Oliveira Fernanda S, Carvalho Natalia B, Vieira Leda Q, Azevedo Vasco, Macedo Gilson C, Oliveira Sergio C
Abstract excerpt
Brucella abortus is a facultative intracellular bacterial pathogen that causes abortion in domestic animals and undulant fever in humans. IFN-γ, IL-12, and CD8+ T lymphocytes are important components of host immune responses against B. abortus. Herein, IFN-γ and IL-12/β2-microglobulin (β2-m) knockout mice were used to determine whether CD8+ T cells and IL-12-dependent IFN-γ deficiency would be more critical to...
Topics
- Animals
- Brucella abortus
- Brucellosis
- Genetic Predisposition to Disease
- Humans
- Interferon-alpha
- Interferon-gamma
- Interleukin-12
- Macrophages
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Spleen