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Host susceptibility to Brucella abortus infection is more pronounced in IFN-γ knockout than IL-12/β2-microglobulin double-deficient mice.

Clinical & developmental immunology - 1 Jan 2012

Brandão Ana Paula M S, Oliveira Fernanda S, Carvalho Natalia B, Vieira Leda Q, Azevedo Vasco, Macedo Gilson C, Oliveira Sergio C

Abstract excerpt

Brucella abortus is a facultative intracellular bacterial pathogen that causes abortion in domestic animals and undulant fever in humans. IFN-γ, IL-12, and CD8+ T lymphocytes are important components of host immune responses against B. abortus. Herein, IFN-γ and IL-12/β2-microglobulin (β2-m) knockout mice were used to determine whether CD8+ T cells and IL-12-dependent IFN-γ deficiency would be more critical to...

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Identifiers

PMID: 22194770
DOI: 10.1155/2012/589494
PMCID: PMC3238360

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Source receipt: pubmed, retrieved 7 Sept 2026.

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