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Brucella abortus nicotinamidase (PncA) contributes to its intracellular replication and infectivity in mice.

FEMS microbiology letters - 15 May 2004

Kim Suk, Kurokawa Daisuke, Watanabe Kenta, Makino Sou-Ichi, Shirahata Toshikazu, Watarai Masahisa

Abstract excerpt

Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in professional and non-professional phagocytes, and cause abortion in domestic animals and undulant fever in humans. The mechanism and factors of virulence are not fully understood. Nicotinamidase/pyrazinamidase mutant (pncA mutant) of Brucella abortus failed to replicate in HeLa cells, and showed a lower rate of...

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PMID: 15135535
DOI: 10.1016/j.femsle.2004.03.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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